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Precautions

Do NOT use Zestoretic if:

• you might be allergic to any ingredient in Zestoretic or any other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
• you possess a history of angioedema (swelling from the face, lips, throat, or tongue)
• you have a good kidney artery narrowing
• you are unable to urinate
• you take dofetilide or ketanserin
• you happen to be pregnant.

Contact your doctor or health care provider immediately if any of these affect you.

Some health concerns may talk with Zestoretic. Tell a medical expert or pharmacist when you have any health conditions, in particular when any of the following sign up for you:

• if you're pregnant, intending to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, or other substances
• if you're able to become pregnant
• in case you have impaired liver function, blood vessel problems (eg, stroke), heart disease (eg, congestive heart failure), or high cholesterol
• if you have a good reputation for kidney artery narrowing or decreased kidney function, you happen to be on dialysis, or you might have had a kidney transplant
• if you have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you might be on a sodium-restricted diet
• in the event you possess a collagen vascular disorder (eg, lupus, scleroderma), bone marrow problems, or severe disease fighting capability problems
• should you have a very reputation allergies or asthma
• if you happen to be scheduled to possess major surgery or receive anesthesia.

Some medicines may talk with Zestoretic. Tell your medical provider in the event you consider some other medicines, especially any in the following:

• Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the chance of electrolyte problems and irregular heartbeat could be increased
• Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) for the reason that chance of low hypertension may be increased
• Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure level may occur
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) because they may decrease Zestoretic's effectiveness
• Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) because their effectiveness could be decreased by Zestoretic.

This is probably not a whole list of all interactions that will occur. Ask your doctor if Zestoretic may interact with other medicines that you are taking. Check with your medical provider before you begin, stop, or affect the dose of any medicine.

Important safety information:

• Zestoretic may cause dizziness, lightheadedness, or fainting. These effects may be worse if you adopt it with alcohol or certain medicines. Use Zestoretic with caution. Do not drive or perform other possible unsafe tasks and soon you recognize how you react to it.
• Zestoretic might cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially inside morning. Sit or lie down on the first sign associated with a of these effects.
• Check along with your doctor prior to deciding to use a salt substitute or possibly a product which has potassium inside it.
• Drink a lot of fluids while taking Zestoretic and prevent doing activities that cause sweating in excess. Dehydration, hyperhidrosis, vomiting, or diarrhea may lead to a fall in blood pressure level. Contact your doctor at the same time if any one these occur.
• Diabetes patients - Zestoretic may raise your blood sugar. High blood glucose levels could make you really feel confused, drowsy, or thirsty. It can also cause you to be flush, breathe faster, or possess a fruit-like breath odor. If these symptoms occur, tell your physician right away.
• A persistent, unproductive cough may occur. Tell your medical professional if this occurs. Recovery is rapid in the event the medicine is stopped.
• Patients having medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine in case you may well not feel "normal." Tell your doctor in case you develop any new symptoms.
• Zestoretic may not act as well in black patients. They may also be at greater probability of negative effects. Contact your doctor if the symptoms tend not to improve or if they become worse.
• Tell your physician or dentist that you adopt Zestoretic before you decide to receive any medical or dental treatments, emergency care, or surgery.
• Zestoretic could cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zestoretic. Use a sunscreen or wear protective clothing in case you have to be outside for more than a short period of time.
• Zestoretic may restrict certain lab tests, including parathyroid function tests. Be sure your medical professional and lab personnel know you are taking Zestoretic.
• Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, and kidney function, could possibly be performed whilst you use Zestoretic. These tests may be used to monitor your condition or search for unwanted side effects. Be sure to keep all doctor and lab appointments.
• Use Zestoretic with caution within the elderly; they could possibly be more sensitive to its effects.
• Zestoretic must be used with extreme caution in youngsters; safety and effectiveness in kids have not been confirmed.
• Pregnancy and breast-feeding: Zestoretic might cause birth defects or fetal death if you take it while you might be pregnant. If you think you could possibly be pregnant, get hold of your doctor right away. Zestoretic can be found in breast milk. Do not breastfeed while taking Zestoretic.