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Precautions

Do NOT use Endep if:

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• you are allergic to any ingredient in Endep

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• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline) within the last 14 days

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• you consider antihistamines (eg, diphenhydramine), cisapride, droperidol, a ketolide (eg, telithromycin) , a macrolide (eg, erythromycin), mibefradil, or pimozide
• you happen to be dealing with heart disease.

Contact your doctor or physician straight away if all of these connect with you.

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Some medical conditions may talk with Endep. Tell your physician or pharmacist if you have any health concerns, in particular when any with the following connect with you:

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• if you happen to be pregnant, likely to conceive, or are breast-feeding

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• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or any other substances
• when you have a good reputation for mental illness (eg, bipolar disorder, mania, manic-depression), or have considered or attempted suicide
• in case you have alcoholism or regularly consume 3 or more alcohol based drinks per day

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• in case you have glaucoma, an irregular heartbeat, cardiovascular disease, chest pain, liver disease, prostate problems, thyroid disease, or cannot urinate (urinary retention)

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Some medicines may talk with Endep. Tell your doctor if you take any other medicines, especially any in the following:

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• MAOIs (eg, phenelzine, selegiline) because they might cause serious, sometimes life-threatening, reactions. Do not take MAO inhibitors with, or within 14 days of taking, Endep

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• Anticholinergics (eg, scopolamine), bupropion, cimetidine, fluconazole, phenothiazines (eg, chlorpromazine), SSRIs (eg, fluoxetine), terbinafine, or valproic acid because unwanted side effects such as blurred vision, difficult urination, drowsiness or sedation, dry mouth, or lightheadedness may occur
• Antihistamines (eg, diphenhydramine), cisapride, droperidol, ketolides (eg, telithromycin), macrolides (eg, erythromycin), mibefradil, pimozide, or streptogramins (eg, quinupristin/dalfopristin) because serious unwanted effects for the heart (eg, racing heartbeat, dizziness, fainting, life-threatening abnormal heartbeat leading to unconsciousness, and not enough heartbeat, could be increased by Endep

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• Carbamazepine, thyroid medicines (eg, levothyroxine), or stimulants (eg, albuterol, pseudoephedrine) as their unwanted effects might be increased by Endep

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• Warfarin because unwanted side effects including serious bleeding could be increased by Endep
• Clonidine, guanethidine, or guanfacine for the reason that effectiveness of the medicines may be decreased.

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This will not be a complete report on all interactions that could occur. Ask your medical provider if Endep may communicate with other medicines that you just take. Check along with your health care provider when you start, stop, or customize the dose from a medicine.

Important safety information:

• Endep could cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything whatsoever else that could be dangerous until you discover how you react to Endep. Using Endep alone, along with other medicines, or with alcohol may lessen your ability drive an automobile or perform other very damaging tasks.

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• Avoid drinking alcohol or taking other medicines that create drowsiness (eg, sedatives, tranquilizers) while taking Endep. Endep will add for the connection between alcohol and other depressants. Ask your pharmacist when you have queries about which medicines are depressants.
• Endep might cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, particularly in the morning. Sit or lay down on the first sign of some of these effects.

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• Involuntary and uncontrollable movements may develop in patients taking Endep. Occurrence is highest one of many elderly, especially women. The risk of developing these involuntary movements and the likelihood they'll become permanent are increased with long-term use and with high doses. However, it's possible to develop these symptoms after short-term use at low doses. Contact your health care provider immediately if any in the following occur: involuntary movements from the tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes combined with involuntary movements of the arms or legs.
• Endep could potentially cause sensitivity to sunlight. Avoid prolonged exposure for the sun along with other ultraviolet light (eg, tanning beds). Use sunscreens and wear protective clothing until tolerance is decided.

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• Do not become overheated in hot weather or during exercise or any other activities since heatstroke may occur.
• Diabetes patients - Endep may affect your blood sugar. Check blood glucose levels closely. Ask a medical expert prior to deciding to affect the dose of one's diabetes medicine.

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• Before you might have any medical or dental treatments, emergency care, or surgery, tell the physician or dentist that you are using Endep.

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• Use caution inside the elderly; they could be more understanding of its effects, especially lightheadedness upon standing; rapid heartbeat; breathing problems; difficult urination; and constipation.
• Pregnancy and breast-feeding: Endep is shown to cause harm towards the human fetus. If you plan on pregnancy, discuss with your doctor the advantages and perils associated with using Endep when pregnant. Endep is excreted inside breast milk. Do not breastfeed while taking Endep.

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