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INDICATIONS

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Detrol is indicated to the treatment of overactive bladder with signs of urge urinary incontinence, urgency, and frequency.

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INSTRUCTIONS

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Take Detrol just as prescribed from your doctor. Do not take in larger or smaller amounts and for more than recommended. Follow the directions on your own prescription label.

Your doctor may occasionally improve your dose to make sure you acquire the best results.

Take Detrol with water. Do not crush, chew, break, or open a controlled-release capsule. Swallow it whole. Breaking or opening the pill might cause excessive drug to be released at one time.

Store Detrol at room temperature far from moisture and heat.

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If you missed a dose - consider the missed dose whenever you remember. Skip the missed dose whether it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

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DOSAGE

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The recommended dose of Detrol Capsules is 4 mg once daily with water and swallowed whole. The dose may be lowered to 2 mg daily based on individual response and tolerability; however, limited efficacy data are for sale for Detrol 2 mg.

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For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B) or severe renal impairment (CCr 10-30 mL/min), the recommended dose of Detrol is 2 mg once daily. Detrol is just not recommended for use within patients with severe hepatic impairment (Child-Pugh Class C). Patients with CCKlO mL/min weren't studied and use of Detrol on this population just isn't recommended.

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For patients who are taking drugs that are potent inhibitors of CYP3A4 [e.g., ketoconazole, clarithromycin, ritonavir], the recommended dose of Detrol is 2 mg once daily.

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STORAGE

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Store Detrol at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store inside the bathroom. Keep Detrol out of your reach of kids and from pets.

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Side Effects

Get emergency medical help in case you have any of these signs of a hypersensitive reaction to Detrol: hives; difficulty breathing; swelling of your respective face, lips, tongue, or throat. Stop using Detrol and call your physician at the same time in case you have all of these serious unwanted effects:

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Less serious Detrol side effects might include:

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This isn't a complete set of unwanted side effects yet others may occur. Call your physician for health advice about unwanted side effects.

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Precautions

Before taking tolterodine, tell your doctor or pharmacist if you are allergic with it; or if you have any other allergies. This product could have inactive ingredients, which may cause hypersensitive reactions or any other problems. Talk to your pharmacist for more information.

This medication should not be used if you have certain medical conditions. Before applying this medicine, consult your doctor or pharmacist if you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a specific eye condition (uncontrolled narrow-angle glaucoma).

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Before applying this medication, tell your physician or pharmacist your history, especially of: other bladder problems (e.g., bladder outflow obstruction), stomach/intestinal disease (e.g., ulcerative colitis), slowed movement of stomach/intestines, severe constipation, controlled narrow-angle glaucoma, kidney disease, liver disease, enlarged prostate, a particular muscle disease (myasthenia gravis).

Tolterodine might cause a condition that affects the guts rhythm (QT prolongation). QT prolongation can infrequently lead to serious (rarely fatal) fast/irregular heartbeat and other symptoms (for example severe dizziness, fainting) that need immediate medical attention. The likelihood of QT prolongation could possibly be increased when you have certain medical conditions or are taking other drugs that could affect the guts rhythm (see also Drug Interactions section). Before using tolterodine, tell your physician or pharmacist if you have the following conditions: certain heart disease (heart failure, slow heartbeat, QT prolongation within the EKG), ancestors and family history of certain heart related illnesses (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium inside the blood could also increase your risk of QT prolongation. This risk may increase if you use certain drugs (including diuretics/"water pills") or for those who have conditions like severe sweating, diarrhea, or vomiting. Talk to your doctor about using tolterodine safely.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or inflict activity that needs alertness or clear vision until you are sure it is possible to perform such activities safely. Limit booze.

This medication might cause decreased sweating. Avoid becoming overheated in hot weather, saunas, or during exercise or other strenuous activities since heatstroke may occur.

Kidney function declines when you age group. This medication is taken away from the kidneys. Therefore, older people could be more sensitive to this drug.

This medication should be used only once clearly needed in pregnancy. It is not known whether Detrol will harm an child. Tell your physician in case you are pregnant or plan to become pregnant while employing this medication. Discuss the hazards and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

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