Methotrexate is used to treat certain types of cancer or to get a grip on severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control rheumatoid arthritis that is juvenile. Methotrexate belongs to a class of drugs called antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
Early remedy for rheumatoid arthritis with more aggressive therapy such as methotrexate assists to reduce further joint damage and to preserve function that is joint.
OTHER USES: This section contains uses of this medication being not placed in the approved labeling that is professional the drug but that could be prescribed by your health care pro. Make use of this medication for a condition that is placed in this part as long as it's been therefore prescribed by your health care professional.
This medicine may also be used for lupus and psoriatic arthritis.
Read the Patient Information Leaflet if available from your pharmacist before you start taking methotrexate and each time you get a refill. If you have any relevant questions, pose a question to your doctor or pharmacist.
Methotrexate is a strong medication. The dosage and how often you take this medication are based on your condition that is medical and to treatment. There are many different dosing schedules for this medication (especially for cancer treatment). Therefore, it is very important that you follow your physician's instructions very carefully. Take this medicine by mouth as directed by your doctor.
For the treating psoriasis or arthritis rheumatoid, just take this medicine by mouth as directed by your medical professional, frequently once per week. It might take as much as a few months before you have the full benefit of this medication.
Do not increase your dose or use this drug more often or for longer than prescribed. Your condition shall not improve any faster, along with your risk of negative effects will increase.
Since this medication could be consumed through skin and lung area and may also harm an unborn baby, ladies who are pregnant or who may get pregnant should not handle this medication or breathe the dust through the tablets.
Drink plenty of liquids while taking this medication unless your physician tells you otherwise. Doing this helps your kidneys to eliminate the drug from the body and steer clear of a number of the relative adverse effects.
See section that is also warning.
Nausea, sickness, stomach pain, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist quickly.
Temporary hair loss might occur. Normal hair regrowth should return after therapy has ended.
Remember that your doctor has recommended this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have side that is serious.
Inform your physician appropriate away if you have any adverse that is serious, including: mouth sores, diarrhea, signs of anemia (such as for instance unusual tiredness, pale skin), signs of liver problems (such as for example dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin), easy bruising/bleeding, black stools, enlarged glands/lymph nodes, bone pain, unusual pain and discoloration of your skin, change in the total amount of urine, dry coughing, muscle weakness.
Get help that is medical away if you have any very severe unwanted effects, including: weakness on one part regarding the body, neck stiffness, serious headache, eyesight changes, irregular heartbeat, mental/mood changes, seizures.
This medication might lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent throat that is sore cough).
This medication can impact sperm production, an impact that may lower fertility that is male. Consult your doctor for more details.
A very serious reaction that is allergic this drug is rare. However, get help that is medical away in the event that you notice any observeable symptoms of a serious allergic reaction, including: rash, itching/swelling (especially regarding the face/tongue/throat), severe dizziness, difficulty breathing.
This is not a list that is complete of side effects. If you notice other effects not listed above, contact your pharmacist or doctor.
In the US -
Phone your doctor for medical advice about unwanted effects. You might report adverse effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
See also Warning section.
Before taking methotrexate, inform your physician or pharmacist if you have any other allergies if you are allergic to it; or. This product may contain ingredients that are inactive that may cause sensitive responses or other issues. Speak to your pharmacist for more information.
Before by using this medication, tell your doctor or pharmacist your medical history, especially of: liver condition, kidney condition, lung disease (such as for instance pulmonary fibrosis), liquor usage, suppressed immune system, blood cell/bone marrow disorders, stomach/intestinal diseases (such as for example peptic ulcer, ulcerative colitis), any active infection (including chickenpox or present exposure to it), folic acid deficiency.
Methotrexate can make you prone to get infections or may worsen any current infections. Consequently, clean your hands well to prevent the spread of infection. Avoid contact with individuals who have infections that may spread to other people (such as chickenpox, measles, flu). Consult your medical professional if you have been exposed to an infection or for more details.
Don't have immunizations/vaccinations without the consent of your physician. Prevent contact with those who have recently received live vaccines (such as for instance flu vaccine inhaled through the nose).
To reduce the possibility of getting cut, bruised, or injured, use caution with razor-sharp objects like razors and nail cutters, and prevent activities such as for example contact sports.
This drug might make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages that are alcoholic.
Before having surgery, tell your physician or dentist about all the products you utilize (including prescription drugs, nonprescription medications, and herbal products).
This medicine may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear clothing that is protective outdoors.
Methotrexate must not be utilized during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy during and after treatment with methotrexate. Therefore, males and females must use reliable forms of birth control (such as condoms, birth control pills) during treatment. Males should continue to use birth control for at least 3 months after the final end of treatment. Females should continue to use birth control for at least 1 cycle that is menstrual the end of treatment. You may be pregnant, tell your doctor right away if you become pregnant or think.
Since this drug can be consumed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not manage this medication or inhale the dust from the tablets.
Methotrexate passes into breast milk and may harm a nursing baby. Therefore, breast-feeding when using this drug isn't recommended. Consult with your medical practitioner before breast-feeding.
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