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Uses

INDICATIONS

Chloroquine is indicated to the suppressive treatment and then for acute attacks of malaria as a result of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for the treating extraintestinal amebiasis.

INSTRUCTIONS

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Take chloroquine with meals or milk to minimize stomach upset, unless otherwise directed from your doctor.

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t is essential which you take chloroquine only as directed. Do not take a greater portion of it, don't take it often, and don't take it a bit longer than your physician ordered. To do so could raise the probability of serious unwanted side effects.

If you take chloroquine to keep from getting malaria, keep taking it to the regular of treatment. If you already have malaria, you should still keep taking chloroquine for your fulltime of treatment in case you commence to feel good soon after days. This will help to up your infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Chloroquine works best whenever you get it on a regular schedule. For example, in case you are to get it once weekly to avoid malaria, it is best to go on the same day every week. Or should you be to take two doses every day, one dose could possibly be taken with breakfast and also the other with the evening meal. Make sure that you simply usually do not miss any doses. If you've any queries about this, consult your wellbeing care professional.

If you miss a dose of chloroquine, get it as soon as possible. However, when it is almost time for your upcoming dose, skip the missed dose and get back to your regular dosing schedule. Do not double doses.

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DOSAGE 

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The dosage of chloroquine phosphate is usually expressed regarding equivalent chloroquine base. Each 500 mg tablet of ARALEN provides the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on the exact same day of every week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of weight, but shouldn't exceed the adult dose in spite of weight.

If circumstances permit, suppressive therapy has to start two weeks before exposure. However, failing this in adults, a basic double (loading) dose of just one g (= 600 mg base), or perhaps in children 10 mg base/kg may be consumed two divided doses, six hours apart. The suppressive therapy ought to be continued for 8 weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of just one g (= 600 mg base) as well as a different 500 mg (= 300 mg base) after six to eight hours as well as a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents an overall total dose of 2.5 g chloroquine phosphate or 1.5 g base in 72 hours.

The dosage for adults of low body weight as well as for infants and children should be determined as follows:

First dose: 10 mg base per kg (and not exceeding an individual dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (and not exceeding a single dose of 300 mg base).

Third dose: (a day after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with an 8-aminoquinoline compound is necessary.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, followed by 500 mg (300 mg base) daily for about 2 to 3 weeks. Treatment is usually combined with the effective intestinal amebicide.

STORAGE 

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Store the medicine in the closed container at room temperature, far from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine will no longer needed.

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Side Effects

Along having its needed effects, medication could potentially cause some negative effects. Although not these negative effects may occur, should they happen they will often need medical help. When chloroquine is used in short amounts of time, side effects tend to be rare. However, when it is employed for quite a while and/or perhaps high doses, unwanted effects will occur and might be serious.

Check with your physician immediately if any of the following negative effects occur:
Less common

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Blurred vision
difference in vision
eye pain
decrease of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or another mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any loss of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The negative effects within the Less Common category above may also occur or become worse as soon as you stop taking chloroquine.

Some unwanted effects may occur very often usually do not need medical assistance. These unwanted effects may go away during treatment as the body adjusts to the medicine. Also, your health care professional could be able to let you know about ways in order to avoid or reduce a few of these unwanted effects. Check with your quality of life care professional if any of the following unwanted side effects continue or are bothersome or if you might have questions about them:

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More common


Diarrhea
difficulty in seeing to read
headache
itching (more widespread in black patients)
lack of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or within mouth
skin rash

Other negative effects unlisted might also appear in some patients. If you notice any other effects, consult your medical practioner.

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Precautions

If you'll be taking chloroquine for a very long time, it is vital that your medical professional check you at regular visits for virtually any blood problems or muscle weakness that could possibly be brought on by chloroquine. In addition, talk with your physician immediately if blurred vision, difficulty in reading, or any other difference in vision occurs during or after treatment. Your doctor might want one to have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms usually do not improve in a couple of days or when they become worse, check with a medical expert.

Make sure you understand how you reply to chloroquine prior to deciding to drive, use machines, or do anything whatsoever else that could be dangerous if you're not able to see well.

Chloroquine could cause blurred vision, difficulty in reading, or any other alternation in vision. It can also cause a lot of people to become lightheaded.

If these reactions are specifically bothersome, seek advice from a medical expert.

Certain medicines should not be used at or around the time of consuming food or eating certain kinds of food since interactions may occur. Using alcohol or tobacco with certain medicines might also cause interactions that occurs. Discuss together with your doctor the usage of your medicine with food, alcohol, or tobacco.

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There are not any adequate and well-controlled studies evaluating the protection and efficacy of chloroquine in women that are pregnant. Usage of chloroquine in pregnancy ought to be avoided except inside the suppression or management of malaria when in the judgment of the physician the power outweighs the potential risk on the fetus.

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