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Uses

INDICATIONS

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Chloroquine is indicated for that suppressive treatment as well as for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for your treating extraintestinal amebiasis.

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INSTRUCTIONS

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Take chloroquine with meals or milk to reduce stomach upset, unless otherwise directed through your doctor.

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t is essential that you just take chloroquine only as directed. Do not take much more of it, do not take it often, and don't take it much more time than your physician ordered. To do so may increase the potential for serious side effects.

If you adopt chloroquine to hold you getting malaria, keep taking it for your fulltime of treatment. If you have malaria, you should still keep taking chloroquine to the fulltime of treatment in case you begin to feel good after a few days. This will help to clear the infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Chloroquine is ideal if you take it on the regular schedule. For example, in case you are to go on it weekly to avoid malaria, it is advisable to go on the same day each week. Or should you be to look at two doses every day, one dose could be taken with breakfast along with the other with all the evening meal. Make sure that you simply don't miss any doses. If you have any queries about it, talk with your health care professional.

If you miss a dose of chloroquine, go at the earliest opportunity. However, when it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

DOSAGE 

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The dosage of chloroquine phosphate is often expressed regarding equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the same as 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on a similar day of each week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of bodyweight, but shouldn't exceed the adult dose in spite of weight.

If circumstances permit, suppressive therapy should begin fourteen days just before exposure. However, failing this in grown-ups, a primary double (loading) dose of 1 g (= 600 mg base), or in children 10 mg base/kg could possibly be taken in two divided doses, six hours apart. The suppressive therapy ought to be continued for eight weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of merely one g (= 600 mg base) as well as yet another 500 mg (= 300 mg base) after six to eight hours plus a single dose of 500 mg (= 300 mg base) on every one of two consecutive days. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in 3 days.

The dosage for adults of low body weight and for infants and children must be determined as follows:

First dose: 10 mg base per kg (however, not exceeding just one dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding just one dose of 300 mg base).

Third dose: (twenty four hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with the 8-aminoquinoline compound is essential.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two main days, followed by 500 mg (300 mg base) daily for about two to three weeks. Treatment is usually combined with the effective intestinal amebicide.

STORAGE 

Store the medicine inside a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of your reach of kids.

Do not keep outdated medicine or medicine no more needed.

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Side Effects

Along having its needed effects, a medicine might cause some negative effects. Although not all of these unwanted side effects may occur, if they do occur they may need medical assistance. When chloroquine is employed for short amounts of time, side effects tend to be rare. However, when it is used for a long time and/or perhaps in high doses, side effects may occur and may be serious.

Check with your doctor immediately if the following unwanted effects occur:
Less common

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Blurred vision
change in vision
eye pain
loss of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or another mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any decrease of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The unwanted side effects within the Less Common category above might also occur or become worse once you stop taking chloroquine.

Some unwanted side effects may occur that usually tend not to need medical assistance. These negative effects might go away during treatment since your body adjusts on the medicine. Also, your health care professional might be able to inform you of ways to stop or reduce many of these unwanted effects. Check with your quality of life care professional if these things unwanted effects continue or are bothersome or if you've questions about them:

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More common


Diarrhea
difficulty in seeing to read
headache
itching (more established in black patients)
loss of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside of mouth
skin rash

Other negative effects unpublished can also appear in some patients. If you notice another effects, seek advice from your doctor.

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Precautions

If you'll be taking chloroquine for a very long time, it is vital that your doctor check you at regular visits for almost any blood problems or muscle weakness that could be caused by chloroquine. In addition, seek advice from your medical professional immediately if blurred vision, difficulty in reading, or another alteration of vision occurs during or after treatment. Your doctor might prefer you to definitely have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms tend not to improve in just a few days or when they become worse, seek advice from your doctor.

Make sure you understand how you react to chloroquine when you drive, use machines, or a single thing else that is dangerous if you're not able to see well.

Chloroquine might cause blurred vision, difficulty in reading, or another change in vision. It might also cause some individuals to get lightheaded.

If these reactions are especially bothersome, talk with your medical professional.

Certain medicines must not be used at or around the time of eating or eating certain kinds of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss together with your medical practioner the use of your medicine with food, alcohol, or tobacco.

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There are not any adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine in pregnancy should be avoided except inside the suppression or treatment of malaria when inside the judgment of the physician the main benefit outweighs the potential risk towards the fetus.

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