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Precautions

Do NOT use Paxil if:

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• you consider or have taken linezolid, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. John's wort within the last 14 days

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• you are taking a fenfluramine derivative (eg, dexfenfluramine), nefazodone, pimozide, a serotonin norepinephrine reuptake inhibitor (SNRI) (eg, venlafaxine), another SSRI (eg, fluoxetine), sibutramine, thioridazine, or tryptophan.

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Contact your physician or health care provider without delay if some of these connect with you.

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Some medical conditions may connect to Paxil. Tell a medical expert or pharmacist in case you have any medical conditions, particularly if any from the following affect you:

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• if you happen to be pregnant, intending to conceive, or are breast-feeding

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• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• in case you have allergies to medicines, foods, or another substances

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• if you or perhaps a member of the family includes a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse

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• for those who have a good seizures, cardiovascular disease, liver problems, severe kidney problems, stomach or bowel bleeding, narrow-angle glaucoma, diabetes, or metabolism problems

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• if you might be dehydrated, have low blood sodium levels, or are drinking alcoholic beverages

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• if you may be having electroconvulsive therapy (ECT).

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Some medicines may interact with Paxil. Tell your doctor if you take every other medicines, especially any from the following:

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• Anorexiants (eg, phentermine), cimetidine, fenfluramine derivatives (eg, dexfenfluramine), linezolid, lithium, MAOIs (eg, phenelzine), metoclopramide, nefazodone, selegiline, serotonin 5-HT₁ receptor agonists (eg, sumatriptan), sibutramine, SNRIs (eg, venlafaxine), another SSRI (eg, fluoxetine), St. John's wort, tramadol, trazodone, or tryptophan because severe negative effects, such as a reaction that will include fever, rigid muscles, blood pressure levels changes, mental changes, confusion, irritability, agitation, delirium, or coma, may occur

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• Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the chance of bleeding, including stomach bleeding, may be increased

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• Diuretics (eg, furosemide, hydrochlorothiazide) as the likelihood of low blood sodium levels may be increased

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• Antiarrhythmics (eg, flecainide, propafenone, quinidine), H₁ antagonists (eg, astemizole, terfenadine), or phenothiazines (eg, chlorpromazine, thioridazine) because severe heart disease, including irregular heartbeat, may occur

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• Cyproheptadine, HIV protease inhibitors (eg, ritonavir), phenobarbital, or phenytoin given that they may decrease Paxil's effectiveness

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• Aripiprazole, atomoxetine, clozapine, fluoxetine, pimozide, procyclidine, risperidone, theophylline, or tricyclic antidepressants (eg, amitriptyline) because the probability of their unwanted effects could possibly be increased by Paxil

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• Digoxin or tamoxifen his or her effectiveness could possibly be decreased by Paxil.

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This is probably not a total report on all interactions that may occur. Ask your health care provider if Paxil may connect to other medicines which you take. Check using your doctor prior to starting, stop, or customize the dose of the medicine.

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Important safety information:

• Paxil could cause drowsiness, dizziness, or blurred vision. These effects could possibly be worse if you get it with alcohol or certain medicines. Use Paxil with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you reply to it.

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• Do not are drinking alcoholic beverages whilst you consider Paxil.

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• Check together with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you might be using Paxil; it could help to increase their effects. Ask the pharmacist in case you have questions on which medicines might cause drowsiness.

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• Several weeks may pass before your symptoms improve. Do NOT take over the recommended dose, change your dose, or use Paxil more than prescribed without checking using your doctor.

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• Children, teenagers, and the younger generation taking Paxil might be at increased risk for suicidal thoughts or actions. Closely watch all patients who take Paxil. Contact the doctor at the same time if new, worsened, or sudden symptoms like depressed mood; anxious, restless, or irritable behavior; anxiety attacks; or any unusual difference in mood or behavior occur. Contact a doctor straight away if any signs of suicidal thoughts or actions occur.

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• If a medical expert lets you know to halt taking Paxil, you will need to watch for a few months before beginning to adopt certain other medicines (eg, MAOIs, nefazodone). Ask a medical expert when you should start to adopt your new medicines after you've stopped taking Paxil.

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• Paxil may rarely result in a prolonged, painful erection. This could happen even when you might be not having sexual intercourse. If this is not treated right away, it could possibly cause permanent sexual difficulties such as impotence. Contact your physician without delay should this happen.

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• Serotonin syndrome is really a possibly fatal syndrome that may be due to Paxil. Your risk may be greater if you take Paxil with certain other medicines (eg, "triptans," MAOIs). Symptoms might include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; hyperhidrosis; and nausea, vomiting, or diarrhea. Contact your medical professional at once when you have all of these symptoms.

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• Neuroleptic malignant syndrome (NMS) is really a possibly fatal syndrome that could be due to Paxil. Your risk might be greater if Paxil is used with certain other medicines called antipsychotics (eg, aripiprazole, risperidone). Symptoms could possibly be comparable to serotonin syndrome and can sometimes include fever, rigid muscles, hypertension changes, and mental changes. Contact a medical expert at the same time when you have some of these symptoms.

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• Use Paxil with caution inside elderly; they may be more sensitive to its effects, especially low blood sodium levels.

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• Caution is advised when working with Paxil in kids; they could possibly be more responsive to its effects, especially increased likelihood of suicidal thoughts and actions.

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• Paxil might cause weight changes. Children and teenagers might need regular weight and growth checks while they take Paxil.

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