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ARAVA is indicated in adults to the treatments for active rheumatoid arthritis (RA):

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Take this medicine only as directed through your doctor. Do not take much more of it, do not take it more frequently, and do not take on it much more time than your physician ordered.

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The dose on this medicine will change for various patients. Follow a medical expert's orders or even the directions for the label. The following information includes exactly the average doses of this medicine. If your dose is unique, usually do not put it back unless a medical expert lets you know for this.

The amount of medicine which you take depends around the strength from the medicine. Also, the number of doses you take every day, enough time allowed between doses, and also the period of time you adopt the medicine depend for the disease for which you are employing the medicine.

For oral dosage form (tablets):

For rheumatoid arthritis symptoms:

If you miss a dose of this medicine, go on it immediately. However, when it is almost time for your forthcoming dose, skip the missed dose and get back on your family dosing schedule. Do not double doses.


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Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F). Protect from light. Keep out with the reach of children. Do not keep outdated medicine or medicine no longer needed. Store the medicine in the closed container at room temperature, faraway from heat, moisture.

 Keep out with the reach of youngsters. Do not keep outdated medicine or medicine don't needed. Store the medicine inside a closed container at room temperature, far from heat, moisture.

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Side Effects

Stop employing this medicine and check with your doctor right away if you are having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

Adverse reactions for this using leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along having its needed effects, medicines could cause some uncomfortable side effects. Although not many of these unwanted effects may occur, if they do occur they will often need medical assistance.

Check with a medical expert immediately if any with the following side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss in appetite
nausea / vomiting
sore throat
tightness inside the chest
yellow eyes or skin
Less common
Burning feeling in the chest or stomach
burning, prickling, or tingling sensation inside fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
shortness of breath
tenderness in the stomach area
unusual tiredness or weakness
Incidence unfamiliar
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening in the skin
blood within the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a sense tiredness or weakness
high fever
large, hive-like swelling around the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
spine or side pain
pains inside stomach, side, or abdomen, possibly radiating for the back
pale skin
pinpoint red spots for the skin
rapid, shallow breathing
red lesions on the skin, often which has a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or for the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside arms, hands, legs, or feet

Some unwanted side effects may occur that always don't need medical attention. These unwanted effects may go away during treatment because your body adjusts for the medicine. Also, your overall health care professional could possibly inform you of ways to prevent or reduce many of these negative effects. Check together with your health care professional if any with the following side effects continue or are bothersome or if you have any questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching with the skin
pain or burning inside throat
runny nose

Other side effects not listed could also happen in some patients. If you notice some other effects, check along with your doctor.

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It is essential that your physician look at progress at regular visits to be sure that this medicine is functional. Blood tests may be required to check on for uncomfortable side effects.

Using this medicine while you are pregnant damages your developing fetus. Use an effective way of birth control method to maintain from conceiving a child. If you think you've get pregnant with all the medicine, tell your doctor immediately.

Leflunomide could also cause birth defects if your father is employing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as being a type of birth control during sexual intercourse. A man aiming to father a youngster should stop investing in this medicine and appearance together with his doctor right away.

Serious skin reactions may appear with this medicine. Stop employing this medicine and check with your physician straight away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; itching; joint or muscle pain; red lesions on the skin, often using a purple center; sores, ulcers, or white spots inside the mouth or for the lips; or unusual tiredness or weakness.

Liver problems may occur while you are utilizing this medicine. Stop employing this medicine and check with your doctor right away if you're having many of such symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss in appetite; nausea / vomiting; skin rash; swelling in the feet or legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the quantity of white blood cells inside your blood, helping the chance of getting an infection. It can also lower the amount of platelets, that happen to be required for proper blood clotting. If this occurs, there are certain precautions you are able to take, specially when your blood count is low, to reduce the chance of infection or bleeding:

Check with a medical expert right away if you might have a cough with or without temperature, shortness of breath, or any difficulty with breathing.

You should have a skin test for tuberculosis prior to starting employing this medicine. Tell your physician should you or anyone in your home has ever endured a good a reaction to a tuberculosis test.

Using this medicine may improve your chance of getting serious infections or cancer. Talk to a medical expert if you have concerns relating to this risk.

Do not take other medicines unless they've been discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamins.

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