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Precautions

Do NOT use Actoplus Met if:

• you happen to be allergic to the ingredient in Actoplus Met
• you have type 1 diabetes
• you've got moderate to severe heart failure
• you possess a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
• you experienced a stroke or a recent cardiac arrest, or you will be in shock
• you're four decades old or maybe more and have not stood a kidney function test
• you is going to be having surgical treatment or certain lab procedures
• you have a reputation liver problems, including jaundice (yellowing with the skin or eyes), during therapy using a similar medicine called troglitazone.

Contact a medical expert or doctor immediately if any of these apply to you.

Some medical ailments may talk with Actoplus Met. Tell a medical expert or pharmacist when you have any health concerns, particularly if any of the following affect you:

• if you might be pregnant, about to get pregnant, or are breast-feeding
• if you happen to be taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, and other substances
• if you have a good heart disease (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis
• for those who have fluid retention or swelling problems, vomiting, diarrhea, bad health or nutrition, low blood calcium or vitamin B₁₂ levels, or anemia, or if you happen to be dehydrated
• when you have an infection, fever, recent injury, or moderate to severe burns
• if you have a very good reputation for bone fracture, weak bones (eg, osteoporosis), or low calcium intake
• if you drink alcohol or use a reputation alcohol abuse
• should you will be having surgical treatment or certain lab procedures
• if you take a beta-blocker (eg, propranolol).

Some medicines may interact with Actoplus Met. Tell your medical provider if you might be taking some other medicines, especially any of the following:

• Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, contraception pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the likelihood of high or low blood sugar might be increased
• Amiloride, cimetidine, digoxin, gemfibrozil, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin given that they might increase the probability of Actoplus Met's negative effects
• Rifampin as it may decrease Actoplus Met's effectiveness, resulting in high blood glucose levels
• Anticoagulants (eg, warfarin) because their effectiveness may be decreased or probability of their unwanted side effects might be increased by Actoplus Met.

This might not be a complete list of all interactions that may occur. Ask your health care provider if Actoplus Met may interact with other medicines that you just take. Check with your medical provider before starting, stop, or change the dose from a medicine.

Important safety information:

• Actoplus Met could potentially cause dizziness. This effect could be worse should you go on it with alcohol or certain medicines. Use Actoplus Met with caution. Do not drive or perform other possibly unsafe tasks until you recognize how you react to it.
• Follow the diet and exercise program presented to you by your health care provider.
• Inform a medical expert if you might be going to are drinking alcohol as you use Actoplus Met.
• Tell your physician or dentist which you take Actoplus Met before you have any medical or dental care, emergency care, or surgery.
• Do not take more than the recommended dose without checking together with your doctor.
• Be careful not to become dehydrated, especially during hot weather, while you might be being active, or if you have vomiting or diarrhea. Dehydration may improve your risk of unwanted effects from Actoplus Met.
• Actoplus Met may cause ovulation in ladies who have not reached menopause such as the ovulate. Women who would like to avoid pregnancy ought to be sure to use effective birth control method while using Actoplus Met.
• Check your blood sugar levels as directed because of your doctor. If they are often higher or below they needs to be and you adopt Actoplus Met exactly as prescribed, tell your physician.
• Actoplus Met does not usually cause low blood glucose. Low blood sugar could be prone to occur if you skip meals, exercise heavily, or are drinking alcohol. It may also be more likely if you're taking Actoplus Met in addition to certain other medicines for diabetes (eg, sulfonylureas, insulin). It is really a good idea to carry a reliable way to obtain glucose (eg, tablets or gel) to treat low blood glucose. If this is not available, you must eat or drink a quick method to obtain sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise the blood sugar levels level quickly. Tell your medical professional straight away in such a circumstance. To prevent low blood sugar, eat meals concurrently daily and don't skip meals.
• Fever, infection, injury, or surgery may enhance your risk for high or low blood glucose levels levels. If all of these occur, look at blood sugar levels closely and tell your doctor straight away.
• Actoplus Met may commonly cause stomach upset, indigestion, nausea, or diarrhea at the beginning of treatment. If you develop unusual or unexpected peptic issues, or in the event you develop stomach problems later during treatment, get hold of your doctor at once. This could possibly be a manifestation of lactic acidosis.
• An increased incidence of bone fracture may be reported in women having Actoplus Met. Tell a medical expert should you have a good bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your doctor immediately in case you experience any unusual bone pain.
• Actoplus Met could possibly be connected with an increased probability of bladder cancer. Discuss questions or concerns along with your doctor.
• Lab tests, including kidney and liver function, fasting blood glucose, hemoglobin A_1c, blood counts, and eye examinations, may be performed when you use Actoplus Met. These tests may be used to monitor your condition or search for negative effects. Be certain to keep all doctor and lab appointments.
• Use Actoplus Met with caution inside the elderly; they might be more responsive to its effects. Low blood sugar levels levels may also be more difficult to identify inside the elderly.
• Actoplus Met shouldn't be utilized in children; safety and effectiveness in kids are not confirmed.
• Pregnancy and breast-feeding: If you get pregnant, speak to your doctor. You will need to discuss the advantages and perils associated with using Actoplus Met while you are pregnant. It is not known if Actoplus Met can be found in breast milk. Do not feed breast while taking Actoplus Met.