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Do NOT use Actoplus Met if:

you are allergic to your ingredient in Actoplus Met
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you use a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
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you also have a stroke or a recent cardiac arrest, or perhaps you have been in shock
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you're eighty years old or maybe more and still have not had a kidney function test
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you use a good reputation for liver problems, including jaundice (yellowing from the skin or eyes), during therapy using a similar medicine called troglitazone.

Contact your doctor or doctor without delay if any of these sign up for you.

Some medical ailments may interact with Actoplus Met. Tell your medical professional or pharmacist for those who have any medical conditions, particularly if any from the following connect with you:

if you are pregnant, about to become pregnant, or are breast-feeding
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when you have allergies to medicines, foods, and other substances
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should you possess a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, an under active thyroid, stomach or irregularity (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis
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when you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B₁₂ levels, or anemia, or if you are dehydrated
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when you have an infection, fever, recent injury, or moderate to severe burns
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Some medicines may interact with Actoplus Met. Tell your health care provider if you're taking any other medicines, especially any of the following:

Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control method pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) for the reason that probability of high or low blood glucose might be increased
Amiloride, cimetidine, digoxin, gemfibrozil, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the chance of Actoplus Met's side effects
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Rifampin since it may decrease Actoplus Met's effectiveness, producing high blood sugar
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Anticoagulants (eg, warfarin) as their effectiveness might be decreased or the chance of their unwanted side effects may be increased by Actoplus Met.

This is probably not a total listing of all interactions which could occur. Ask your health care provider if Actoplus Met may interact along with other medicines that you simply take. Check with your health care provider before you start, stop, or change the dose of the medicine.

Important safety information:

Actoplus Met may cause dizziness. This effect may be worse in the event you take it with alcohol or certain medicines. Use Actoplus Met with caution. Do not drive or perform other possibly unsafe tasks before you discover how you reply to it.
Follow the dieting and exercise program directed at you by your doctor.
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Inform your doctor if you might be going to are drinking alcoholic beverages while you use Actoplus Met.
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Tell a medical expert or dentist that you just take Actoplus Met prior to deciding to receive any medical or dental care, emergency care, or surgery.
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Be careful not to become dehydrated, especially during summer, while you're being active, or in case you have vomiting or diarrhea. Dehydration may increase your probability of negative effects from Actoplus Met.
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Actoplus Met may cause ovulation in women who have not reached menopause but do not ovulate. Women who need to avoid pregnancy must be sure to use effective contraception while using Actoplus Met.
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Check your blood sugar levels as directed through your doctor. If they are often higher or below they should be and you are taking Actoplus Met the same manner prescribed, tell a medical expert.
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Actoplus Met will not usually cause low blood glucose levels. Low blood sugar could possibly be prone to occur in the event you skip dinner, exercise heavily, or drink alcohol. It may also be a little more likely if you adopt Actoplus Met as well as certain other medicines for diabetes (eg, sulfonylureas, insulin). It is a good option to transport a dependable supply of glucose (eg, tablets or gel) to help remedy low blood glucose levels. If this is not available, you need to eat or drink an instant way to obtain sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will increase your blood glucose level quickly. Tell your doctor immediately in such a circumstance. To prevent low blood sugar levels, eat meals simultaneously daily , nor skip meals.
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Fever, infection, injury, or surgery may raise your risk for high or low blood sugar levels. If all of these occur, look at blood glucose levels closely and tell your doctor without delay.
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Actoplus Met may commonly cause stomach upset, indigestion, nausea, or diarrhea at the start of treatment. If you develop unusual or unexpected nausea, or should you develop peptic issues later during treatment, contact your doctor simultaneously. This may be a symbol of lactic acidosis.
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An increased incidence of bone fracture may be reported in females taking Actoplus Met. Tell your physician in the event you have a history of bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your doctor immediately in the event you experience any unusual bone pain.
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Actoplus Met could possibly be of an increased probability of bladder cancer. Discuss any questions or concerns using your doctor.
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Lab tests, including kidney and liver function, fasting blood sugar, hemoglobin A_1c, blood counts, and eye examinations, could possibly be performed while you use Actoplus Met. These tests may be used to monitor your complaint or check for unwanted effects. Be sure to keep all doctor and lab appointments.
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Use Actoplus Met with caution inside the elderly; they might be more understanding of its effects. Low blood sugar levels may also be a little more difficult to identify inside the elderly.
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Actoplus Met mustn't be utilized in children; safety and effectiveness in youngsters have not been confirmed.
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Pregnancy and breast-feeding: If you get pregnant, contact your doctor. You will need to discuss the rewards and perils associated with using Actoplus Met while you happen to be pregnant. It is not known if Actoplus Met is situated in breast milk. Do not feed breast while taking Actoplus Met.
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