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Precautions

Do NOT use Estrace if:

• you are allergic to the ingredient in Estrace
• you are pregnant or suspect you may be pregnant, have recently given birth or are breast-feeding, or have vaginal bleeding of abnormal or unknown cause
• you've got known or suspected cancer of the breast (unless directed because of your doctor) otherwise you have cancers which are estrogen-dependent
• you've blood clots, vein inflammation, or liver disease
• you experienced a recent stroke or heart attack.

Contact your doctor or doctor without delay if some of these affect you.

Some health concerns may communicate with Estrace. Tell your medical professional or pharmacist if you have any medical ailments, particularly when any in the following affect you:

• in case you are planning to become pregnant
• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, and other substances
• in case you have a genealogy of cancer of the breast, or you have breast lumps or disease, or an abnormal mammogram
• for those who have yellowing of the whites from the eyes or skin during pregnancy or with past estrogen use, or hypertension while pregnant (toxemia)
• in case you have a vaginal infection or womb problems (eg, uterine fibroids/endometriosis, abnormal vaginal bleeding, other uterine problems)
• for those who have abnormal calcium levels inside the blood, asthma, cancer, certain blood disorder (porphyria), cholesterol or lipid problems, depression, diabetes, epilepsy, excessive weight gain, gallbladder disease, heart disease or other heart related illnesses, hypertension, kidney or liver disease, low thyroid hormonal changes, lupus, migraines, pancreas disease, seizures, or yellowing with the skin or eyes
• in the event you smoke or is going to be having surgery.

Some medicines may connect to Estrace. Tell your health care provider if you adopt another medicines, especially any of the following:

• Blood thinners (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, or tacrine as their actions and the chance of their side effects could be increased by Estrace
• Blood thinners (eg, warfarin) as their effectiveness may be decreased by Estrace
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin since they may decrease Estrace's effectiveness.

This will not be a total list of all interactions which could occur. Ask your medical provider if Estrace may connect to other medicines which you take. Check with your health care provider prior to starting, stop, or customize the dose of any medicine.

Important safety information:

• Estrace might cause dizziness. This effect could possibly be worse if you get it with alcohol or certain medicines. Use Estrace with caution. Do not drive or perform other possible unsafe tasks before you know how you react to it.
• Limit alcohol based drinks if you are taking Estrace.
• Estrace could cause dark skin patches on the face (melasma). Exposure on the sun might make these patches darker and you'll need to avoid prolonged sun damage and sunlamps. Consult your physician in connection with using sunscreens and protective clothing.
• Estrace could raise the risk of blood clots. The risk may be greater in the event you smoke (particularly in women much older than 35 years old).
• Contact a medical expert if vaginal bleeding of unknown cause occurs. This could be a sign of a significant condition requiring immediate medical attention.
• Contact a medical expert if vaginal discomfort occurs or if you suspect you've got developed contamination while taking Estrace.
• Follow your physician's instructions for examining your breasts and report any lumps immediately.
• Additional monitoring of your dose or condition might be necessary if you're presently taking an azole antifungal (eg, itraconazole), carbamazepine, a macrolide antibiotic (eg, erythromycin), ritonavir, cimetidine, or St. John's wort.
• If you wear contact lenses and you develop difficulty with them, speak to your doctor.
• If you will likely be having surgery or will be confined to a chair or bed for long periods of time (eg, an extended plane flight), notify your physician beforehand. Special precautions may have to be studied during these circumstances while you're taking Estrace.
• Nonprescription therapy to help prevent bone loss incorporates a weight-bearing fitness plan, as well as adequate daily calcium and vitamin D intake. Consult a medical expert or pharmacist for more details.
• Some of these products may contain the dye tartrazine (FD&C Yellow No. 5), that may cause allergic reactions using patients. Consult your doctor or pharmacist. If you previously had allergic reactions for the dye tartrazine, speak to your doctor or pharmacist to determine in the event the product you're taking contains the dye tartrazine.
• Estrace may restrict certain tests. Be sure your doctor and lab personnel know you are taking Estrace.
• Diabetes patients - Estrace may affect your blood glucose levels. Check blood sugar levels levels closely. Ask your doctor when you change the dose of one's diabetes medicine.
• Lab tests, including physical exams and hypertension, could possibly be performed as you use Estrace. You should have breast and pelvic exams, plus a Pap test at least once annually. You should also have periodic mammograms as determined from your doctor. Be sure to keep all doctor and lab appointments.
• Estrace really should not be utilized in children; safety and effectiveness in youngsters are not confirmed.
• Pregnancy and breast-feeding: Do not use Estrace if you are pregnant. Avoid pregnancy if you are taking it. If you think you could be pregnant, contact your doctor without delay. Estrace may be present in breast milk. If you are or will probably be breast-feeding while you use Estrace, check using your doctor. Discuss any possible risks to your baby.