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ARAVA is indicated in adults for that treatments for active rheumatism (RA):

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Take this medicine only as directed from your doctor. Do not take really it, do not take on it more frequently, and do not take on it much more time than your physician ordered.

The dose on this medicine will be different for different patients. Follow a medical expert's orders or the directions around the label. The following information includes exactly the average doses of the medicine. If your dose differs, don't change it out unless your medical professional lets you know to take action.

The volume of medicine that you just take depends for the strength in the medicine. Also, the amount of doses you're taking on a daily basis, some time allowed between doses, and the time period you take the medicine depend for the disease that you are using the medicine.

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For oral dosage form (tablets):

For arthritis rheumatoid:

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If you miss a dose of the medicine, go immediately. However, when it is almost time for your forthcoming dose, skip the missed dose and go back to your family dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions able to 15-30°C (59-86°F). Protect from light. Keep out with the reach of children. Do not keep outdated medicine or medicine no more needed. Store the medicine inside a closed container at room temperature, faraway from heat, moisture.

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 Keep out in the reach of kids. Do not keep outdated medicine or medicine don't needed. Store the medicine in the closed container at room temperature, away from heat, moisture.


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Side Effects

Stop by using this medicine and check with a medical expert right away if you are having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

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Adverse reactions from the usage of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, medication may cause some negative effects. Although not many of these unwanted effects may occur, if they occur they could need medical help.

Check with your doctor immediately if any in the following unwanted effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
lack of appetite
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling inside chest or stomach
burning, prickling, or tingling sensation inside fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
difficulty breathing
tenderness in the stomach area
unusual tiredness or weakness
Incidence unfamiliar
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening with the skin
blood inside stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general sense of tiredness or weakness
high fever
large, hive-like swelling about the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
small of the back or side pain
pains within the stomach, side, or abdomen, possibly radiating towards the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red skin lesions, often with a purple center
red, irritated eyes
sores, ulcers, or white spots within the mouth or on the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside the arms, hands, legs, or feet

Some unwanted effects may occur very often usually do not need medical assistance. These unwanted side effects might go away during treatment because your body adjusts towards the medicine. Also, your overall health care professional may be able to let you know about methods to prevent or reduce many of these unwanted side effects. Check along with your health care professional if any in the following negative effects continue or are bothersome or if you might have questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness with the mouth
itching in the skin
pain or burning inside the throat
runny nose

Other unwanted side effects unpublished may also appear in some patients. If you notice every other effects, check along with your doctor.



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It is vital that your medical professional look at the progress at regular visits to ensure that this medicine is functional. Blood tests may be required to test for negative effects.

Using this medicine if you are pregnant may damage your unborn baby. Use an effective type of contraceptive to maintain from conceiving. If you think you have become pregnant when using the medicine, tell a medical expert right away.

Leflunomide might also cause birth defects if the father is applying it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms being a kind of birth control method during sex. A man aiming to father a young child should stop using this medicine and appearance together with his doctor right away.

Serious skin reactions can happen using this medicine. Stop applying this medicine and look with your medical professional right away if you might have any of the following symptoms while investing in this medicine: blistering, peeling, or loosening in the skin; chills; itching; joint or muscle pain; red lesions on the skin, often having a purple center; sores, ulcers, or white spots inside the mouth or for the lips; or unusual tiredness or weakness.

Liver problems may occur while you are utilizing this medicine. Stop employing this medicine and look with your physician right away in case you are having more than one of such symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; lack of appetite; queasiness; skin rash; swelling of the feet or calves; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the volume of white blood cells within your blood, improving the possibility of getting disease. It can also lower the number of platelets, that happen to be necessary for proper blood clotting. If this occurs, there are specific precautions you can take, especially when your blood count is low, to lessen the potential risk of infection or bleeding:

Check with your doctor straight away if you've got a cough with or without nausea, lack of breath, or any risk with breathing.

You will need to have a skin test for tuberculosis before starting using this medicine. Tell your doctor in case you or anyone inside your home has had a positive reply to a tuberculosis test.

Using this medicine may raise your likelihood of getting serious infections or cancer. Talk to a medical expert if you have concerns about this risk.

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Do not take other medicines unless to remain discussed with a medical expert. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamins.

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