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ARAVA is indicated in adults to the treatments for active rheumatism (RA):


Take this medicine only as directed because of your doctor. Do not take really it, don't take on it more regularly, and don't take on it for a longer time than your doctor ordered.

The dose with this medicine vary many different patients. Follow your doctor's orders or the directions about the label. The following information includes exactly the average doses of the medicine. If your dose is unique, do not change it out unless a medical expert notifys you to do this.

The amount of medicine that you just take depends on the strength in the medicine. Also, the amount of doses you take each day, some time allowed between doses, along with the period of time you adopt the medicine depend about the medical problem for which you are employing the medicine.

For oral dosage form (tablets):

For rheumatoid arthritis symptoms:

If you miss a dose of this medicine, go on it at the earliest opportunity. However, whether it is almost time for your next dose, skip the missed dose and get back to your normal dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light. Keep out with the reach of kids. Do not keep outdated medicine or medicine no longer needed. Store the medicine in a very closed container at room temperature, far from heat, moisture.

 Keep out of the reach of youngsters. Do not keep outdated medicine or medicine will no longer needed. Store the medicine inside a closed container at room temperature, from heat, moisture.


Side Effects

Stop employing this medicine and check with a medical expert without delay in case you are having burning, numbness, tingling, or painful sensations within the arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

Adverse reactions from the usage of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along having its needed effects, medicines could potentially cause some unwanted side effects. Although not many of these negative effects may occur, should they happen they may need medical assistance.

Check with your doctor immediately if any from the following unwanted effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss of appetite
nausea / vomiting
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling inside chest or stomach
burning, prickling, or tingling sensation inside the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
tenderness within the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening in the skin
blood inside the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling about the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
back or side pain
pains within the stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots around the skin
rapid, shallow breathing
red skin lesions, often having a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or around the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside arms, hands, legs, or feet

Some negative effects may occur have a tendency to usually do not need medical help. These unwanted effects might have to go away during treatment as your body adjusts towards the medicine. Also, your quality of life care professional may be able to let you know about solutions to prevent or reduce a few of these unwanted side effects. Check using your health care professional if any with the following unwanted effects continue or are bothersome or if you've got any questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness from the mouth
itching in the skin
pain or burning inside throat
runny nose

Other unwanted effects not listed can also happen in some patients. If you notice any other effects, check along with your medical practioner.



It is very important that your physician look at the progress at regular visits to make sure that this prescription medication is functional. Blood tests may be needed to evaluate for uncomfortable side effects.

Using this medicine if you are pregnant can harm your developing fetus. Use an effective kind of birth control to maintain from conceiving a child. If you think you've got become pregnant with all the medicine, tell your doctor straight away.

Leflunomide could also cause birth defects in the event the father is using it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a form of contraceptive during sex. A man planning to father a child should stop investing in this medicine and appearance together with his doctor without delay.

Serious skin reactions can happen using this medicine. Stop by using this medicine and look with your medical professional right away if you've got any in the following symptoms while investing in this medicine: blistering, peeling, or loosening with the skin; chills; itching; joint or muscle pain; red wounds, often which has a purple center; sores, ulcers, or white spots in the mouth or about the lips; or unusual tiredness or weakness.

Liver problems may occur while you are using this medicine. Stop employing this medicine and check with a medical expert straight away if you're having many of such symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; decrease of appetite; nausea / vomiting; skin rash; swelling in the feet or calves; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the amount of white blood cells inside your blood, enhancing the potential for getting an infection. It can also lower the volume of platelets, that happen to be needed for proper blood clotting. If this occurs, there are particular precautions you'll be able to take, particularly if your blood count is low, to relieve the chance of infection or bleeding:

Check with your doctor right away if you've a cough with or without temperature, shortness of breath, or any risk with breathing.

You needs to have a skin test for tuberculosis before you begin employing this medicine. Tell your physician in the event you or anyone inside your home has ever endured an optimistic reaction to a tuberculosis test.

Using this medicine may enhance your risk of getting serious infections or cancer. Talk to a medical expert if you might have concerns about it risk.

Do not take other medicines unless they have been discussed with a medical expert. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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