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Baclofen is employed for treating spasm of skeletal muscles that create muscle clonus, rigidity, and pain because of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (otherwise known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter within the brain. Neurotransmitters are chemicals that nerves use to communicate together. GABA released by some nerves causes the experience of other nerves to reduce. It is believed that Baclofen, acting like GABA, blocks the experience of nerves inside part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.

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The usual starting dose of Baclofen for adults is 5 mg three times daily. Based on the response, the dose might be increased gradually every 3 days to a maximum of 80 mg/day in many doses.

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Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of kids.

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Baclofen could potentially cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low hypertension, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

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Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).

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Use of Baclofen with other drugs that also depress the function of nerves may lead to additional reduction in brain function.

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In addition on the probability of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.

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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may lead to greater depression of brain function and also low blood pressure level.

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As Baclofen can increase blood sugar levels, doses of antidiabetic drugs should be adjusted when Baclofen is taken.

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The use of Baclofen by expecting mothers will not be evaluated.

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Baclofen might be detected inside the breast milk of mothers taking oral Baclofen. No facts are entirely on the existence of Baclofen in the breast milk of mothers receiving Baclofen intrathecally.

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