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Precautions

Do NOT use Duetact if:

• you are allergic to any ingredient in Duetact
• you might have moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems related to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or very high blood acid levels (acidosis)
• you've type 1 diabetes
• you are taking bosentan.

Contact your doctor or physician immediately if any of these connect with you.

Some health concerns may connect to Duetact. Tell your physician or pharmacist if you have any health concerns, in particular when any with the following sign up for you:

• if you happen to be pregnant, likely to become pregnant, or are breast-feeding
• in the event you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, or any other substances
• if you have had an extreme hypersensitivity (eg, severe rash, hives, , etc ., dizziness) to any other sulfonamide medicine including acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• if you have a history of kidney, thyroid, heart, or circulatory problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or low levels of the enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• if you have stomach or bowel obstruction (eg, stomach or bowel blockage, stomach paralysis), drink alcohol, or also have poor nutrition
• in case you have inadequate health, a high fever, a serious infection, severe diarrhea, high blood acid levels, or brain or neurological system problems, or experienced a severe injury
• for those who have a history of bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• for those who have swelling problems (edema) or certain eye problems (macular edema)
• if you may be having surgery.

Some medicines may interact with Duetact. Tell your doctor in case you are taking every other medicines, especially any from the following:

• Bosentan because liver problems may occur, along with the effectiveness of both medicines could possibly be decreased
• Beta-blockers (eg, propranolol) for the reason that risk of low blood glucose levels might be increased. They may also hide certain signs of low blood sugar to make it more difficult to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) as the probability of low blood sugar levels could be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control method pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) since they may decrease Duetact's effectiveness, producing high blood sugar levels
• Gemfibrozil because blood glucose could be increased or decreased
• Anticoagulants (eg, warfarin) his or her effectiveness might be decreased or probability of their unwanted effects could possibly be increased by Duetact.

This might not be an entire listing of all interactions that may occur. Ask your health care provider if Duetact may communicate with other medicines that you just take. Check with your health care provider before you start, stop, or customize the dose of any medicine.

Important safety information:

• Duetact could potentially cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you get it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks before you understand how you respond to it.
• Do not consume alcohol when you consider Duetact; it could increase the likelihood of low blood sugar. Rarely, alcohol may communicate with Duetact and create a serious reaction with symptoms including flushing, nausea, vomiting, dizziness, or stomach pain. Discuss any queries or concerns along with your doctor.
• Carry an ID card at all times that says you've got diabetes.
• Proper diet and exercise are important as a way to shed weight whilst rid of it. Follow the diet and exercise program given to you because of your doctor.
• Check your blood glucose levels levels as directed because of your doctor. If they are often higher or lower than they should be and also you take Duetact just as prescribed, tell your physician.
• It may be harder to manage your blood sugar levels during times of stress such as fever, infection, injury, or surgery. Talk along with your doctor about how to manipulate your blood sugar if some of these occur. Do not customize the dose of your medicine without checking together with your doctor.
• Do not take a lot more than the recommended dose without checking using your doctor.
• Duetact may cause low blood sugar levels levels. Low blood glucose levels might make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your pulse faster; help make your vision change; give you a headache, chills, or tremors; or allow you to more hungry. It is really a wise decision to hold a reliable source of glucose (eg, tablets or gel) to treat low blood glucose levels. If this is not available, you need to eat or drink a fast source of sugar like ordinary sugar, honey, candy, orange juice, or non-diet soda. This will raise the blood glucose level quickly. Tell your medical professional immediately if this happens. To prevent low blood glucose, eat meals concurrently on a daily basis , nor skip meals.
• Risk of low blood sugar levels might be increased by severe or prolonged exercise, having a drink, or skipping meals.
• Duetact posesses a sulfonylurea. It may boost the risk of death from cardiovascular disease. Talk using your doctor concerning the benefits and perils of this or any other therapies to take care of your problem.
• Duetact could potentially cause ovulation in women that have not reached menopause along with ovulate. To avoid pregnancy, be sure to utilize effective birth control with all the Duetact.
• Duetact may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths unless you know how you react to Duetact. Use a sunscreen or wear protective clothing in case you must be outside for greater than a limited time.
• Tell a medical expert or dentist that you simply take Duetact prior to deciding to have any medical or dental care, emergency care, or surgery.
• Duetact might be linked to an increased likelihood of bladder cancer. Discuss any queries or concerns using your doctor.
• An increased incidence of bone fracture has been reported in ladies who take Duetact. Tell your doctor in case you have a good bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell a medical expert right away in case you experience any unusual bone pain.
• Lab tests, including fasting blood glucose, hemoglobin A_1c, liver function, and eye exams, could possibly be performed when you use Duetact. These tests could possibly be used to monitor your problem or look for unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution in the elderly; they could possibly be more understanding of its effects, specially the chance of heart problems or low blood glucose.
• Duetact should not be utilized in children; safety and effectiveness in kids weren't confirmed.
• Pregnancy and breast-feeding: Duetact could potentially cause injury to the fetus or newborn. If you think you could be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Duetact while you happen to be pregnant. It is not known if Duetact is found in breast milk. Do not breastfeed while taking Duetact.

When used by extended periods of time Duetact may not are well. If your blood sugar levels has been in order and then becomes hard to manage, get hold of your doctor. Do not affect the dose of one's medicine without checking with your doctor.