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Precautions

Do NOT use Depakote if:

• you're allergic to any ingredient in Depakote
• you might have liver problems or perhaps a urea cycle disorder.

Contact your doctor or physician right away if some of these connect with you.

Some health conditions may connect to Depakote. Tell your doctor or pharmacist in case you have any medical ailments, especially if any from the following connect with you:

• if you're pregnant, intending to become pregnant, are breast-feeding
• in case you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, and other substances
• for those who have a history of abusive drinking, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood degrees of ammonia or glutamine, low temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low numbers of white blood cells, or if you might be scheduled for surgery
• for those who have a good reputation for ornithine transcarbamylase deficiency or unexplained coma
• for those who have a family history of urea cycle disorders or unexplained infant deaths
• if you have a reputation mental or mood problems (eg, depression), or suicidal thoughts or actions
• if you're taking another medicine for seizures.

Some medicines may talk with Depakote. Tell your medical provider in case you are taking some other medicines, especially any from the following:

• Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) since the likelihood of serious side effects of Depakote, including adjustments to vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, could possibly be increased
• Clonazepam because the likelihood of seizures may be increased
• Topiramate as the probability of high ammonium levels, brain problems, or even an unusual drop in temperature could possibly be increased
• Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, contraception pills), or rifampin given that they may decrease Depakote's effectiveness
• Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine since the chance of their unwanted effects could be increased by Depakote.

This might not be a complete report on all interactions that may occur. Ask your medical provider if Depakote may talk with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of the medicine.

Important safety information:

• Depakote might cause drowsiness, dizziness, or blurred vision. These effects could possibly be worse in case you go with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you respond to it.
• Do not are drinking alcohol or use medicines that could potentially cause drowsiness (eg, sleep aids, muscle relaxers) while you're using Depakote; it may well increase their effects. Ask the pharmacist if you have questions about which medicines might cause drowsiness.
• Inflammation in the pancreas is really a potentially life-threatening illness associated with Depakote. Symptoms include stomach pain, vomiting, or decrease of appetite. Contact your physician at the same time if all of these symptoms occur.
• Patients having Depakote may be at increased risk for suicidal thoughts or actions. The risk could possibly be greater in patients who've had suicidal thoughts or actions in the past. Patients who've bipolar (manic-depressive) illness can also provide an increased risk for suicidal thoughts or actions. Watch patients taking Depakote closely. Contact your physician at once if new, worsened, or sudden symptoms, for example depressed mood; anxious, restless, irritable behavior; panic disorder; or any unusual change in mood or behavior occur. Contact the physician straight away if any signs of suicidal thoughts or actions occur.
• Depakote may reduce the quantity of clot-forming cells (platelets) with your blood. Avoid activities that could potentially cause bruising or injury. Tell your medical professional in case you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
• Tell your physician or dentist that you take Depakote before you decide to have any medical or dentistry, emergency care, or surgery.
• Diabetes patients - Depakote may cause the results of some tests for urine ketones to become wrong. Ask a medical expert before you improve your diet or the dose of one's diabetes medicine.
• Depakote may increase the ammonia levels within your blood. Contact your doctor without delay if you experience unexplained sluggishness and vomiting or mental changes.
• Depakote could cause a silly drop in temperature (hypothermia). Symptoms may include confusion, not enough energy, lack of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact a medical expert without delay in case you have any of these symptoms.
• Depakote may restrict certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Depakote
• Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, could possibly be performed whilst you use Depakote. These tests could be used to monitor your problem or pay attention to unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Depakote with caution inside elderly; they could possibly be more understanding of its effects, especially drowsiness.
• Depakote must be in combination with extreme caution in youngsters younger than ten years old; safety and effectiveness of these children are not confirmed. Children younger two years may be at increased chance of serious liver problems.
• Pregnancy and breast-feeding: Depakote can harm the fetus. Use an effective form of contraception while you're taking Depakote. If you think you may be pregnant or if you wish to become pregnant, contact your doctor. You will need to discuss the benefits and perils associated with using Depakote if you are pregnant. Depakote is located in breast milk. Do not breastfeed when you are taking Depakote.