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Uses

INDICATIONS

Indinavir can be an antiviral medication inside a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying inside you. It is utilized to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.

INSTRUCTIONS

Take indinavir the same manner it was prescribed to suit your needs. Do not take the medication in larger amounts, or go on it for longer than recommended because of your doctor. Follow the directions on the prescription label.

This medication includes patient instructions for effective and safe use. Follow these directions carefully. Ask your physician or pharmacist in case you have questions.
Take indinavir which has a full glass (8 ounces) of water or skim milk. You can also drink juice, coffee, or tea with this medication. Drink at the very least 6 glasses of water on a daily basis to stop kidney stones if you are taking indinavir. Indinavir should be taken on a clear stomach, no less than one hour before or a couple of hours following a meal.

If you prefer to take the medication with food, eat just a light meal, for example dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is very important to make use of indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of drugs completely.

To make sure prescription drugs helps your problem, your blood will need to be tested frequently. Your liver function might also need to be tested. Do not miss any scheduled visits to your doctor.

HIV/AIDS is generally treated which has a combination of different drugs. To best treat your problem, use all of your medications as directed because of your doctor. Be sure to read the medication guide or patient instructions supplied with each of your respective medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain beneath the good care of a doctor.

Take the missed dose whenever you remember and take your next dose on the regularly scheduled time. If you are more than couple of hours late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to make inside the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis ought to be initiated as soon as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is among the alternative regimens suitable for nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy must start promptly, preferably within 1 to a couple of hours postexposure. The exact use of therapy varies based on the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence towards the prescribed dose is important. Patients must not alter the dose or discontinue therapy without conferring with their physician.

Adequate hydration (1.5 liters/day) is important during therapy to relieve the potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation may be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

Store indinavir at room temperature far from moisture as well as heat. Keep the capsules inside their original container, with the packet of moisture-absorbing preservative that is sold with indinavir capsules.

Side Effects

Get emergency medical help in case you have some of these signs of a hypersensitive reaction: hives; difficulty breathing; swelling of your respective face, lips, tongue, or throat. Stop taking indinavir and call your physician at once when you have these serious side effects:

Less serious negative effects might include:

This is just not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome complication.

Precautions

Do not take medicines should you be allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines including ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening unwanted effects if you are using them if you are taking indinavir.

Before taking indinavir, tell your physician in case you are allergic to any drugs, or in case you have:

If you might have these conditions, you will need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication might be damaging to an developing fetus. Tell your medical professional if you're pregnant or intend to become pregnant during treatment. HIV could be passed to the baby if the mother is not properly treated when pregnant. Take all of the HIV medicines as directed to take control of your infection when you are pregnant.

Your name may must be listed on an antiviral pregnancy registry once you start using medicines.
You should not breast-feed if you are using indinavir. Women with HIV or AIDS ought not breast-feed at all. Even if your child arrives without HIV, you may still pass the herpes simplex virus to the baby in your breast milk.


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